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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bradykinin
supplement:
Progesterone
Research Papers that Mention the Interaction
“Here, we demonstrate that within minutes, progesterone inhibits oxytocin- and bradykinin-induced contractions of rat uteri, calcium responses induced by platelet-activating factor in the human endometrial cell line MFE-280, and oxytocin-induced calcium signals in PHM1-31 immortalized pregnant human myometrial cells.”
Depletion of calcium stores contributes to progesterone-induced attenuation of calcium signaling of G protein-coupled receptors“Preincubation of the cells for 3 h with cortisol (5X10(-7)M - 5X10(-5)M), progesterone (10(-6)M) or mepacrine (10(-6)M - 2X10(-4)M) inhibited the response to histamine, bradykinin and PMA but not to arachidonate.”
“RESULTS In response to …(-7)M br dykinin, p orcine coronary artery rings treated with 1 x 10(-6), 1 … 10(-5) and 5 x 10(-5) g/L of pro gesterone sh owed a significant reduction in endothelium-dependent vasorelaxation by 36%, 45%, … 68%, respectively, as compared to controls (P <0.05).”
Effects of progesterone and estrogen on endothelial dysfunction in porcine coronary arteries.“A low concentration of progesterone (1 nM), with no effects of its own, shifted the relaxation curves of bradykinin and calcium ionophore A23187 to the right while not affecting those of sodium nitroprusside and levcromakalim.”
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