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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bradykinin
supplement:
Potassium
Research Papers that Mention the Interaction
“ Bradykinin (BK), a hormone inducing pain and inflammation, is known to inhibit potassium M-currents (IM) and to increase the excitability of the superior cervical ganglion (SCG) neurons by activating the Ca2+-calmodulin pathway.”
PIP2 Mediated Inhibition of TREK Potassium Currents by Bradykinin in Mouse Sympathetic Neurons“In the strips which reached a steady state 2 hr after administration of potassium , phospholipase A2 and bradykinin produced marked oscillations.”
“The long‐term exposure of DRG neurons to bradykinin enhanced the SP release by capsaicin, but attenuated that by potassium.”
Substance P release evoked by capsaicin or potassium from rat cultured dorsal root ganglion neurons is conversely modulated with bradykinin“BACKGROUND The bradykinin (BK)-induced endothelium-dependent relaxation is impaired in the presence of elevated potassium concentration enhancing the vasospastic tendency of large coronary arteries.”
“The M‐potassium current was inhibited by bath application of 100 μM ATP, 10 nM bradykinin , 100 nM angiotensin II and 100 nM endothelin 1 as well as by 10 μM acetylcholine in an ml‐muscarinic acetylcholine receptor‐transformed NG108‐15 cell line.”
“In NG108-15 cells, bradykinin BK ) activates a potassium current (IK,BK) and inhibits the voltage-dependent calcium current (ICa,V).”
“Previous studies have demonstrated that bradykinin hyperpolarizes the cell membrane of subconfluent MDCK cells by increase of the potassium conductance.”
“[Ca2+]i increase induced by high potassium depolarization was suppressed by bradykinin.”
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