Possible Interaction: Bradykinin and Methionine

“Acute focal application of M or KATP channel enhancers or a hyperpolarization‐activated cyclic nucleotide‐gated channel blocker to L5 DRG in vivo significantly alleviated pain induced by hind paw injection of bradykinin.”

“ Bradykinin , a pain producing substance, augmented the production of opioid peptides, for example, methionine and leucine enkephalins in in vitro and in vivo experiments.”

“Statistically significant (p < 0.01) reactions were observed at 10−7 M and higher concentrations of bradykinin.”

“The addition of a lysine moiety (in e.g. Lys-BK) or methionine and lysine moieties (in e.g. Met-Lys-BK) to BK not only can decrease the affinity of the resultant peptides for the kinin receptor in HUAV but the instrinsic activity as well.”

“In response to bradykinin at 10−5 M , the endothelium-dependent relaxation was significantly reduced for RTV, APV, and SQV.”

“Combining M and R individually with T resulted in a significantly larger inhibition of the bradykinin response than with each of the drugs given separately.”

“ BK induces a dose-related contraction of lung parenchymal strips which is increased significantly in the presence of 10−5 M captopril (an angiotensin converting enzyme inhibitor) or 10−5 M dl-thiorphan (a neutral endopeptidase inhibitor).”

“Incubation with indomethacin 10−5 M ) prevented the augmentation of the relaxations induced by bradykinin , but not those caused by adenosine diphosphate.”

“Transport of methionine , valine and glucose was also enhanced by addition of bradykinin to the serosal fluid of the everted intestine, but no enhancement of glutamic acid transport was observed under the same conditions.”