supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Bradykinin
supplement:
Melatonin
Research Papers that Mention the Interaction
“We hypothesized that melatonin supplementation in a compromised pregnancy enhances the bradykinin (BK)-induced relaxations of placental arteries thereby ensuring sufficient umbilical blood flow to the developing fetus.”
Effect of maternal nutrient restriction and melatonin supplementation from mid to late gestation on vascular reactivity of maternal and fetal placental arteries.“Thus, here we show that melatonin reduces NO production induced by bradykinin by a mechanism upstream to the interaction of Ca2+–calmodulin with NOS.”
“Finally, experiments where melatonin was applied between successive BK stimulation periods showed an enhancement of the agonist‐evoked Ca2+ entry in BAE and SDR cells.”
“However, preincubating SHR aortic endothelial cells with exposure to melatonin increased the internal Ca2+ release triggered by bradykinin (BK) and ATP while stimulating the related agonist‐evoked Ca2+ entry.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback