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Last Updated: 2 years ago

Possible Interaction: Bradykinin and Melatonin

supplement:

Melatonin

Research Papers that Mention the Interaction

We hypothesized that melatonin supplementation in a compromised pregnancy enhances the bradykinin (BK)-induced relaxations of placental arteries thereby ensuring sufficient umbilical blood flow to the developing fetus.
Placenta  •  2014  |  View Paper
Thus, here we show that melatonin reduces NO production induced by bradykinin by a mechanism upstream to the interaction of Ca2+–calmodulin with NOS.
Journal of pineal research  •  2006  |  View Paper
Finally, experiments where melatonin was applied between successive BK stimulation periods showed an enhancement of the agonist‐evoked Ca2+ entry in BAE and SDR cells.
However, preincubating SHR aortic endothelial cells with exposure to melatonin increased the internal Ca2+ release triggered by bradykinin (BK) and ATP while stimulating the related agonist‐evoked Ca2+ entry.
Journal of pineal research  •  2002  |  View Paper