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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bradykinin
supplement:
Masoprocol
Research Papers that Mention the Interaction
“The selective CYP 2C9 inhibitor sulfaphenazole and the superoxide anion (O2−) scavengers Tiron and nordihydroguaretic acid also induced a leftward shift in the NO-mediated concentration-relaxation curve to bradykinin.”
Endothelium-Derived Hyperpolarizing Factor Synthase (Cytochrome P450 2C9) Is a Functionally Significant Source of Reactive Oxygen Species in Coronary Arteries“ Bradykinin-induced actin breakdown and cortical actin formation were respectively prevented by indomethacin, a cyclooxygenase inhibitor, and nordihydroguaiaretic acid , a lipoxygenase inhibitor.”
“Methylene blue, a blocker of cytosolic guanylate cyclase and therefore of the production of guanosine 3',5'-cyclic monophosphate (2nd messenger of endothelium-derived relaxing factor, EDRF), and nordihydroguaiaretic acid , an inhibitor of EDRF, both prevented this endothelium-dependent effect of BK.”
Bradykinin: potential for vascular constriction in the presence of endothelial injury.“ NDGA caused a moderate inhibition of the bradykinin‐induced prostaglandin release and slightly attenuated the bradykinin relaxation (neither effect of NDGA was statistically significant).”
“The lipoxygenase inhibitor, nordihydroguaiaretic acid , inhibited to a similar extent the release of TXA2 by Bk , LTC4 and Paf‐acether but also reduced directly the formation of TXA2 from arachidonic acid, invalidating its use as a specific antilipoxygenase agent.”
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