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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bradykinin
supplement:
Leucine
Research Papers that Mention the Interaction
“In isolated and perfused small bovine coronary arteries, administration of cathepsin L (200 ng/ml) markedly attenuated endothelium-dependent vasodilator responses to bradykinin or A23187 by 56.16+/-9.58% and 68.95+/-10.32%, respectively.”
Dependence of cathepsin L-induced coronary endothelial dysfunction upon activation of NAD(P)H oxidase.“Promethazine, antazoline, diphenhydramine and l -isoproterenol also partially blocked the edema induced by bradykinin.”
“The substitution for leucine , isoleucine and valine which have a bulky and hydrophobic side chain in 4-positions of bradykinin, [Thr6] - bradykinin and [Thr (Ac) 6] - bradykinin caused serious loss of activity. [”
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