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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bradykinin
supplement:
Hydroxocobalamin
Research Papers that Mention the Interaction
“NG-nitro-l-arginine methyl ester and ODQ (inhibitors of nitric oxide [NO] synthase and guanylyl cyclase, respectively) and the NO scavenger hydroxocobalamin , either alone or in combination, shifted the bradykinin concentration-response curve to the right.”
Mediators of Bradykinin-Induced Vasorelaxation in Human Coronary Microarteries“The guanylyl cyclase inhibitor ODQ and the NO scavenger hydroxocobalamin induced a larger shift of the bradykinin CRC than the NO synthase inhibitor L‐NAME, although all three inhibitors equally suppressed bradykinin‐induced cGMP responses.”
Bradykinin‐induced relaxation of coronary microarteries: S‐nitrosothiols as EDHF?“The NO synthase inhibitor N (G)-nitro-L-… (L-NAME; 100 microM) and the NO scavenger hydroxocobalamin (200 microM) each produced … shift in the bradykinin concentration-response curve [pEC(50): L-NAME, 8.9+/-0.1 ( n =… <0.01); hydroxocobalamin, 8.3+/-0.2, ( n =6; P <0.001)].”
“Hoe 140 and hydroxocobalamin fully blocked the inotropic effect of bradykinin.”
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