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Last Updated: 2 years ago

Possible Interaction: Bradykinin and Genistein

supplement:

Genistein

Research Papers that Mention the Interaction

In addition, genistein promoted an increased response to a third exposure to the agonist when applied after washing the cells that had been previously challenged with two increasing doses of bradykinin.
Journal of cellular biochemistry  •  2000  |  View Paper
Our results suggest that the down-regulation of ACE with a consequent change in the circulating levels of angiotensin II (Ang II), vasorelaxant angiotensin-(1-7) [Ang-(1-7)] and bradykinin plays an important role in cardiovascular effects of genistein through the ERK1/2 pathway.
Life sciences  •  2006  |  View Paper
On the other hand, genistein (a tyrosine kinase inhibitor) was able to inhibit thapsigargin (3.12 ± 0.22, n = 5, vs. 1.28 ± 0.16, n = 4, p < 0.001) as well as BK responses (6.46 ± 0.66 vs. 2.89 ± 0.61, n = 4, p < 0.05).
Nephron  •  2002  |  View Paper
Tyrphostine A23 and genistein (tyrosine kinase inhibitors) decreased the bradykinin (10 n M)-induced IP3 production potentiated by 2 n M insulin from 400.7 ± 19.4 pmol/mg protein to 297.3 ± 42.4 and 314.3 ± 37.5 pmol/mg protein, respectively.
Journal of cardiovascular pharmacology  •  2002  |  View Paper
Genistein and tyrphostin A-23, tyrosine kinase inhibitors, completely reversed the elevated IP3 formation by BK and insulin.
Diabetes  •  2000  |  View Paper
Genistein , a specific tyrosine kinase inhibitor, prevented the phosphorylation of ERK2 by BK.
The American journal of physiology  •  1998  |  View Paper
Genistein , an inhibitor of tyrosine kinase, did not affect baseline diameter of the basilar artery but inhibited vasodilatation in response to acetylcholine and bradykinin , without affecting vasodilatation produced by sodium nitroprusside.
Hypertension  •  1998  |  View Paper
Bradykinin- and InsP4-induced Ca2+ influx was blocked by 10-100 microM genistein , a tyrosine kinase inhibitor.
The Biochemical journal  •  1996  |  View Paper
In addition, genistein partially inhibited BK stimulation of inositol phosphate formation.
The Journal of biological chemistry  •  1991  |  View Paper
Genistein , a specific tyrosine kinase inhibitor, prevented the phosphorylation of ERK2 by BK.
American journal of physiology. Renal physiology  •  1998  |  View Paper