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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Bradykinin
supplement:
Edetic Acid
Research Papers that Mention the Interaction
“ Bradykinin … mMEDTA (A, B, D, E and G), 1 mMM 2-mercaptoethanol (A, B, C and G), 0.1 microM Hg2+ (A, C and G), 0.… mM Zn2+ (C), 60 microM BPP5a and 40 microM BPP9a (D), 0.1 microM phosphoramidon (E) and 3 mM sodium p-hydroxymercuribenzoate (G).”
Endopeptidase and carboxypeptidase activities in human urine which hydrolyze bradykinin.“The … towards bradykinin was inhibited by EDTA and 1, 10 phenanthroline, as expected for a metalloenzyme, and also by apstatin (IC50, 1 microM), a selective inhibitor of mammalian AP-P. A Km of 45 microM and an optimum pH of 7-8 was observed with bradykinin as the substrate.”
Functional expression and characterization of the cytoplasmic aminopeptidase P of Caenorhabditis elegans.“Superfusion with calcium-free media and EDTA increased basal renin release 2.5-fold, and bradykinin stimulated a twofold increase in renin release.”
“Hydrolysis of bradykinin had a pH optimum of 7 and was inhibited by low concentrations (10−6M) of ethylenediaminetetraacetic acid or the nonapeptide pyroglutamyl (Pyr)-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro.”
“The enzyme expressed maximum activity at pH 8.0 and 40 degrees C. Oligopeptidase activity on bradykinin was inhibited strongly by 1,10-phenantroline and EDTA and partly by p-chloromercuribenzoic acid but not by phosphoramidon or phenylmethylsulfonyl fluoride.”
Characterization of an intracellular oligopeptidase from Lactobacillus paracasei
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