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“The activity of the nematode AP-P, like its mammalian counterparts, was strongly influenced by metal ions, with Co2+ , Mn2+ and Zn2+ all inhibiting the hydrolysis of bradykinin.”
European journal of biochemistry • 2001 | View Paper
“The Ca2+ channel blockers Co2+ (1-5 mM), Mn2+ (2-6 mM) and nifedipine (1-20 microM), but not desmethoxyverapamil (100 microM) inhibited the hyperpolarizing effect of bradykinin.”