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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Bradykinin and Carrageenan



Research Papers that Mention the Interaction

Subplantar injection of carrageenan led to an increase in immunoreactive bradykinin and metabolic product, desArg9bradykinin.
Thus, bradykinin appears to be a major mediator of increased vascular permeability in response to carrageenan.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
The bradykinin B1 and B2 receptor antagonists (desArg9[Leu8]bradykinin and HOE 140) each reduced neutrophil accumulation to carrageenin in wild-type animals (p < 0.05), but did not cause further reduction of the suppressed response of knockout mice.
The Journal of Immunology  •  2000  |  View Paper
7 These data show that bradykinin can initiate the cascade of cytokine release that mediates hyperalgesic responses to carrageenin and endotoxin (1 μg).
British journal of pharmacology  •  1993  |  View Paper