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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bradykinin
supplement:
Carrageenan
Research Papers that Mention the Interaction
“Subplantar injection of carrageenan led to an increase in immunoreactive bradykinin and metabolic product, desArg9bradykinin.”
“Thus, bradykinin appears to be a major mediator of increased vascular permeability in response to carrageenan.”
A bradykinin antagonist inhibits carrageenan edema in rats“The bradykinin B1 and B2 receptor antagonists (desArg9[Leu8]bradykinin and HOE 140) each reduced neutrophil accumulation to carrageenin in wild-type animals (p < 0.05), but did not cause further reduction of the suppressed response of knockout mice.”
“7 These data show that bradykinin can initiate the cascade of cytokine release that mediates hyperalgesic responses to carrageenin and endotoxin (1 μg).”
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