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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bradykinin
supplement:
Capsaicin
Research Papers that Mention the Interaction
“ Capsaicin pre‐treatment caused significant inhibition of … responses (95% CI) to both bradykinin (from 51.5 [39.7–63.3] mm2 to 16.2 [8.0–24.5] mm2) (P < 0.… 108.4 [80.4–136.4] mm2 to 52.3 [37.1–67.1] mm2) (P < 0.01).”
“In addition, the effect of topical capsaicin was to completely inhibit the bradykinin induced weal response compared to control, the mean weal area (95% CI) being reduced from 13.4(11.4–15.4) mm2 to 8.2 (5.3–11.0) mm2 (P < 0.01).”
“Our findings show that repealed topical application with capsaicin led to a significant reduction of the skin responses to intradermal injections with both agonists, and particularly with bradykinin.”
Effect of topical application with capsaicin on skin responses to bradykinin and histamine in man“ Bradykinin , which activates PKC, also enhanced the response to capsaicin in DRG neurones.”
“… BK was … CPS (cough number after PGE2 = 4.20 ± 0.42; p < 0.001, and after BK = 3.64 ± 0.37; p < 0.01), compared to … ratio after PGE2 = 6.1; p < 0.01, and after BK = 4.2; p < 0.05), compared to diluent (2.5–3.3).”
“The inhibitory effect of ruthenium red and capsaicin on the bradykinin response may be due to inhibition of thromboxane A2 release or arachidonic mobilisation.”
“Repeated injections of capsaicin and bradykinin produced tachyphylaxis (and cross‐tachyphylaxis) and greatly reduced the SP‐evoked flare.”
“After activation by bradykinin , wild-type afferents had increased mechanosensitivity, whereas, after capsaicin exposure, mechanosensitivity was reduced: these changes were absent in TRPA1(-/-) mice.”
The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli.“The long‐term exposure of DRG neurons to bradykinin enhanced the SP release by capsaicin , but attenuated that by potassium.”
“In contrast to the control group, increased Fos expression was found following the use of both capsaicin and bradykinin in a variety of areas of the brain.”
“Administration of low doses of capsaicin or acidified saline did not produce nociception when administered alone, but caused a pronounced effect when administered in association with a subthreshold dose of BK.”
“Capsaicin desensitization greatly reduced BK‐induced nociception, but in contrast, the desensitization to BK increased the capsaicin response.”
“In cells expressing TRPV1, ATP or bradykinin increased the currents evoked by capsaicin or protons through activation of metabotropic P2Y or B2 bradykinin receptors.”
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