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Last Updated: 3 years ago

Possible Interaction: Bradykinin and Capsaicin



Research Papers that Mention the Interaction

Capsaicin pre‐treatment caused significant inhibition of … responses (95% CI) to both bradykinin (from 51.5 [39.7–63.3] mm2 to 16.2 [8.0–24.5] mm2) (P < 0.… 108.4 [80.4–136.4] mm2 to 52.3 [37.1–67.1] mm2) (P < 0.01).
In addition, the effect of topical capsaicin was to completely inhibit the bradykinin induced weal response compared to control, the mean weal area (95% CI) being reduced from 13.4(11.4–15.4) mm2 to 8.2 (5.3–11.0) mm2 (P < 0.01).
Our findings show that repealed topical application with capsaicin led to a significant reduction of the skin responses to intradermal injections with both agonists, and particularly with bradykinin.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology  •  1992  |  View Paper
Bradykinin , which activates PKC, also enhanced the response to capsaicin in DRG neurones.
The Journal of physiology  •  2001  |  View Paper
BK was … CPS (cough number after PGE2 = 4.20 ± 0.42; p < 0.001, and after BK = 3.64 ± 0.37; p < 0.01), compared to … ratio after PGE2 = 6.1; p < 0.01, and after BK = 4.2; p < 0.05), compared to diluent (2.5–3.3).
Scientific reports  •  2020  |  View Paper
The inhibitory effect of ruthenium red and capsaicin on the bradykinin response may be due to inhibition of thromboxane A2 release or arachidonic mobilisation.
European journal of pharmacology  •  1995  |  View Paper
Repeated injections of capsaicin and bradykinin produced tachyphylaxis (and cross‐tachyphylaxis) and greatly reduced the SP‐evoked flare.
The British journal of dermatology  •  1992  |  View Paper
After activation by bradykinin , wild-type afferents had increased mechanosensitivity, whereas, after capsaicin exposure, mechanosensitivity was reduced: these changes were absent in TRPA1(-/-) mice.
Gastroenterology  •  2009  |  View Paper
The long‐term exposure of DRG neurons to bradykinin enhanced the SP release by capsaicin , but attenuated that by potassium.
Journal of neurochemistry  •  2006  |  View Paper
In contrast to the control group, increased Fos expression was found following the use of both capsaicin and bradykinin in a variety of areas of the brain.
Neurosignals  •  2004  |  View Paper
Administration of low doses of capsaicin or acidified saline did not produce nociception when administered alone, but caused a pronounced effect when administered in association with a subthreshold dose of BK.
Capsaicin desensitization greatly reduced BK‐induced nociception, but in contrast, the desensitization to BK increased the capsaicin response.
British journal of pharmacology  •  2004  |  View Paper
In cells expressing TRPV1, ATP or bradykinin increased the currents evoked by capsaicin or protons through activation of metabotropic P2Y or B2 bradykinin receptors.
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology  •  2003  |  View Paper
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