Possible Interaction: Bradykinin and Calcium Supplement

“Thus, NO production by endothelial cells is stimulated by factors that increase intracellular calcium concentration including receptor-dependent agonists like acetylcholine, bradykinin , substance P, and … * Corresponding author.”

“Homologous desensitization of the B2 receptor was observed after repeated applications of bradykinin , which resulted in attenuated changes in intracellular calcium.”

“Treatment of the cultured guinea-pig tracheal smooth muscle cells with methylprednisolone 10–5 M for 6 h increased … bradykinin receptors; this response reached a maximum of 78% and returned to the basal value after 12 h. Bradykinin (10–12 … sixfold higher calcium level in treated … in control cells.”

“ Bradykinin and endothelin-1 reduced total cell Ca by up to 56% in HF-15 cells, COS-7 cells, and CHO K1 cells transfected with the rat B2 receptor cDNA.”

“In fura‐2‐loaded human periodontal ligament (HPDL) cells, bradykinin induced a rapidly transient increase and subsequently sustained increase in cytosolic Ca2+ ([Ca2+]i).”

“ Bradykinin stimulates the influx of calcium ions into the ileum; it is ineffective if no extracellular calcium ions into the ileum; it is ineffective if no extracellular calcium ions are available.”

“Results demonstrate that both EPI and BK induce increases in intracellular calcium and NO levels.”

“Studies have shown that BK promotes the intracellular movement of calcium in human gingival fibroblasts by binding to the B2 receptor.”

“We have reported that the pro-inflammatory mediator bradykinin BK ) promotes larger Ca2+i signals in CF compared with normal bronchial epithelia, a response that reflects endoplasmic reticulum (ER)/Ca2+ store expansion induced by chronic luminal airway infection/inflammation.”

“If Ca2+ is released from a caged Ca2+ compound, the resulting Ca2+ peak is much smaller in the presence of BK than in its absence.”