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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bradykinin
supplement:
Ascorbate
Research Papers that Mention the Interaction
“ Ascorbate (50 and 150 μM) induced a time (max at 2–3 h)‐dependent inhibition of the EDHF‐mediated component of vasodilatation to bradykinin or acetylcholine in perfused segments, but not in rings.”
“ Ascorbate (50 μM) failed to inhibit bradykinin‐induced vasodilatation at a flow rate of 1.25 ml min−1 or below, but produced graded blockade at the higher flow rates of 2.5 and 5 ml min−1.”
Requirement for flow in the blockade of endothelium‐derived hyperpolarizing factor (EDHF) by ascorbate in the bovine ciliary artery“In the bovine eye, EDHF‐mediated vasodilator responses induced by acetylcholine or bradykinin were powerfully blocked when ascorbate (50 μM) was included in the perfusion medium for at least 120 min; with acetylcholine a normally‐masked muscarinic vasoconstrictor response was also uncovered.”
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