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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bradykinin
supplement:
Arachidonate
Research Papers that Mention the Interaction
“Both bradykinin (EC50=8 ng/ml) and the ionophore A23187 (EC50=3×10−7 M) potently stimulated arachidonate release and prostaglandin synthesis in porcine aortic endothelial cells.”
The role of calcium in the regulation of prostacyclin synthesis by porcine aortic endothelial cells“ Bradykinin was found to stimulate very potently arachidonic acid release from cells prelabelled with [3H]arachidonate , the response being dose-dependent and half-maximal at 8 ng/ml.”
“The rate of release of label (primarily arachidonate ) from cells was increased by bradykinin (100 ng/ml) approximately 8-fold, with a return to control levels by 10 min.”
“ Bradykinin treatment stimulated a rapid hydrolysis of [3H]arachidonate from the cellular lipids and conversion of the released acid to PGE2, which was secreted into the medium.”
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