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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Bradykinin and Arachidonate



Research Papers that Mention the Interaction

Both bradykinin (EC50=8 ng/ml) and the ionophore A23187 (EC50=3×10−7 M) potently stimulated arachidonate release and prostaglandin synthesis in porcine aortic endothelial cells.
Lipids  •  2006  |  View Paper
Bradykinin was found to stimulate very potently arachidonic acid release from cells prelabelled with [3H]arachidonate , the response being dose-dependent and half-maximal at 8 ng/ml.
The rate of release of label (primarily arachidonate ) from cells was increased by bradykinin (100 ng/ml) approximately 8-fold, with a return to control levels by 10 min.
Biochimica et biophysica acta  •  1982  |  View Paper
Bradykinin treatment stimulated a rapid hydrolysis of [3H]arachidonate from the cellular lipids and conversion of the released acid to PGE2, which was secreted into the medium.
Prostaglandins  •  1979  |  View Paper