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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Botulinum Toxins, Type A and Glycine

Research Papers that Mention the Interaction

Recent studies have demonstrated that the botulinum neurotoxins inhibit the release of acetylcholine, glutamate, GABA, and glycine in central nerve system (CNS) neurons.
Journal of pharmacological sciences  •  2012  |  View Paper
In summary, the present results showed that A2NTX acts purely presynaptically and inhibits the release machinery of transmitters such as glycine and glutamate, and the transmitter release machinery became less sensitive to intracellular free-Ca(2+) in A2NTX poisoned nerve terminals.
Journal of pharmacological sciences  •  2012  |  View Paper
A2NTX (0.1-1 pM) initially augmented and then decreased amplitude and frequency of spontaneous miniature release of glycine or GABA (mIPSCs) concentration-dependently.
Toxicon : official journal of the International Society on Toxinology  •  2010  |  View Paper
Recent studies have demonstrated that the botulinum neurotoxins inhibit the release of acetylcholine, glutamate, GABA, and glycine in central nerve system (CNS) neurons.
  •  2012  |  View Paper
In summary, the present results showed that A2NTX acts purely presynaptically and inhibits the release machinery of transmitters such as glycine and glutamate, and the transmitter release machinery became less sensitive to intracellular free-Ca2+ in A2NTX poisoned nerve terminals.
  •  2012  |  View Paper