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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Bortezomib
supplement:
Epigallocatechin
Research Papers that Mention the Interaction
“ EGCG directly reacted with BZM and blocked its proteasome inhibitory function; as a consequence, BZM could not trigger endoplasmic reticulum stress or caspase-7 activation, and did not induce tumor cell death.”
“This pronounced antagonistic function of EGCG was evident only with boronic acid-based proteasome inhibitors ( BZM , MG-262, PS-IX), but not with several non-boronic acid proteasome inhibitors (MG-132, PS-I, nelfinavir).”
“Unexpectedly, we discovered that various green tea constituents, in particular (-)-epigallocatechin gallate (EGCG) and other polyphenols with 1,2-benzenediol moieties, effectively prevented tumor cell death induced by BZM in vitro and in vivo.”
Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors.
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