Possible Interaction: Boron and Phosphoric Acid

“High enantio- and diastereoselectivities were found due to the closed six-membered chair-like transition state, with backbone modifications of the boronate and its interactions with the chiral phosphoric acid being the most likely contributing factor.”

“Computational studies revealed that minimization of steric interactions between the alkyl groups of the diol on boron and the chiral phosphoric acid catalyst influences the orientation of α-vinyl substituent of the allylboronate reagent to occupy a pseudo-axial position in the transition state.”