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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“It is well established that curcumin strongly chelates several metal ions, including boron , cobalt, copper, gallium, gadolinium, gold, lanthanum, manganese, nickel, iron, palladium, platinum, ruthenium, silver, vanadium, and zinc.”
Metal–Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin“Simple modifications of the curcumin structure raise the IC50 value but complexes of the central dihydroxy groups of curcumin with boron lower the IC50 to a value as low as 6 microM. The boron complexes are also time-dependent inactivators of the HIV proteases.”
“The increased affinity of the boron complexes may reflect binding of the orthogonal domains of the inhibitor in interesecting … within the substrate-binding cavity of the enzyme, while activation of the alpha, beta-unsaturated carbonyl group of curcumin by … to boron probably accounts for time-… inhibition of the enzyme.”
Inhibition of the HIV-1 and HIV-2 proteases by curcumin and curcumin boron complexes.
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