Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 months ago

Possible Interaction: Bombesin and Tyrosine



Research Papers that Mention the Interaction

Bombesin and gastrin releasing peptide increase tyrosine phosphorylation and can act synergistically with EGF, as well as independently.
International journal of oncology  •  2002  |  View Paper
Moreover, this effect of bombesin on pp125FAK tyrosine phosphorylation requires the presence of both active PKC and cytoskeleton … GF 109203X, as well as by disruption of the cytoskeleton with cytochalasin D. We also show that bombesin … tyrosine phosphorylation of a 95-kDa protein (… alpha v in PC-3 cells.
pp125FAK tyrosine phosphorylation was stimulated by bombesin and mimicked by PKC activation with the tumor-promotor phorbol 12-myristate-13-acetate (PMA).
International journal of cancer  •  1997  |  View Paper
Bombesin rapidly stimulated tyrosine phosphorylation of FAK in a dose dependent manner.
The Journal of surgical research  •  1996  |  View Paper
BBS stimulated intracellular tyrosine phosphorylation of multiple proteins, with a predominant protein of apparent molecular weight of 125 kDa.
Journal of cellular physiology  •  1994  |  View Paper
Bradykinin (BK) and bombesin BN ) stimulate an increase in the tyrosine phosphorylation of a 120-kDa group of proteins (pps120) in Swiss 3T3 cells (Leeb-Lundberg, L. M. F., and Song X.-H. (1991) J. Biol.
The Journal of biological chemistry  •  1993  |  View Paper
In contrast, bombesin , which is an even better mitogen for Swiss 3T3 cells than TNF, stimulated the tyrosine phosphorylation of 41,000-Mr and 43,000-Mr proteins only to a limited extent.
The Biochemical journal  •  1990  |  View Paper
In BOR5 and BOR15 cells, bombesin rapidly stimulated the tyrosine phosphorylation of multiple proteins Mr 110 000-130 000 and 70 000-80 000 including p125fak and paxillin, at low concentrations (half maximum 0.3 nM).
Oncogene  •  1996  |  View Paper
Phosphoamino acid analysis of this phosphorylated protein reveals that EGF and bombesin stimulate phosphorylation on tyrosine , threonine and serine residues.
The Biochemical journal  •  1993  |  View Paper
Although its receptor does not feature a cytoplasmic tyrosine kinase domain, bombesin rapidly stimulates the tyrosine phosphorylation of multiple protein substrates, which are however quite distinct from the usual targets of tyrosine kinase receptors.
Advances in enzyme regulation  •  1993  |  View Paper
Treatment of quiescent Swiss 3T3 … with the mitogenic peptides bombesin , vasopressin, endothelin/vasoactive intestinal contractor (VIC), and … strikingly increased the initial rate of tyrosine phosphorylation measured in anti-phosphotyrosine immunoprecipitates of a major band of Mr 115,… (p115) and two minor components of Mr 90,000 and 75,000.
The Journal of biological chemistry  •  1991  |  View Paper