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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Bradykinin (BK) and bombesin BN ) stimulate an increase in the tyrosine phosphorylation of a 120-kDa group of proteins (pps120) in Swiss 3T3 cells (Leeb-Lundberg, L. M. F., and Song X.-H. (1991) J. Biol.”
Identification of p125, a component of a group of 120-kDa proteins that are phosphorylated on tyrosine residues in response to bradykinin and bombesin stimulation, in anti-ras-GTPase-activating protein immunoprecipitates of Swiss 3T3 cells.“In contrast, bombesin , which is an even better mitogen for Swiss 3T3 cells than TNF, stimulated the tyrosine phosphorylation of 41,000-Mr and 43,000-Mr proteins only to a limited extent.”
“ Bombesin and gastrin releasing peptide increase tyrosine phosphorylation and can act synergistically with EGF, as well as independently.”
“Moreover, this effect of bombesin on pp125FAK tyrosine phosphorylation requires the presence of both active PKC and cytoskeleton … with GF 109203X, as well as by disruption of the cytoskeleton with cytochalasin D. We also show that bombesin … tyrosine phosphorylation of a 95‐kDa protein (… αv in PC‐3 cells.”
“pp125FAK tyrosine phosphorylation was stimulated by bombesin and mimicked by PKC activation with the tumor‐promotor phorbol 12‐myristate‐13‐acetate (PMA).”
“ Bombesin rapidly stimulated tyrosine phosphorylation of FAK in a dose dependent manner.”
“ BBS stimulated intracellular tyrosine phosphorylation of multiple proteins, with a predominant protein of apparent molecular weight of 125 kDa.”
“In BOR5 and BOR15 cells, bombesin rapidly stimulated the tyrosine phosphorylation of multiple proteins Mr 110 000-130 000 and 70 000-80 000 including p125fak and paxillin, at low concentrations (half maximum 0.3 nM).”
The bombesin/GRP receptor transfected into Rat-1 fibroblasts couples to phospholipase C activation, tyrosine phosphorylation of p125FAK and paxillin and cell proliferation.“Phosphoamino acid analysis of this phosphorylated protein reveals that EGF and bombesin stimulate phosphorylation on tyrosine , threonine and serine residues.”
“Although its receptor does not feature a cytoplasmic tyrosine kinase domain, bombesin rapidly stimulates the tyrosine phosphorylation of multiple protein substrates, which are however quite distinct from the usual targets of tyrosine kinase receptors.”
“ Bombesin stimulated p130 tyrosine phosphorylation with kinetics and concentration dependence similar to those observed for p125FAK.”
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