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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bombesin
supplement:
Polypeptides
Research Papers that Mention the Interaction
“RESULTS In CP patients basal and bo besin st imulated PP le vels were significantly (p<0.01) reduced compared to controls only when exocrine insufficiency was present.”
Pancreatic polypeptide secretion in patients with chronic pancreatitis and after pancreatic surgery.“ Bombesin produced a rise in plasma neurotensin from 32 +/- 6 to 61 +/- 19 pmol/l and of PP from 26 +/- 8 to 36 +/- 7 pmol/l.”
“ Bombesin at 2.4 pmol kg-1 min-1 produced significant rises in plasma insulin, glucagon, pancreatic polypeptide, gastrin, cholecystokinin, motilin, glucose-dependent insulinotropic polypeptide, neurotensin, enteroglucagon, vasoactive intestinal polypeptide , and serum calcium.”
“ Bombesin was infused in a dose of 150 ng/kg.hr, resulting in a rise of plasma PP from 24 +/- 5 to 224 +/- 25 pM (p less than 0.01).”
“We examined the question whether the concomitant release of PP exerts a suppressive action on the pancreatic exocrine response to bombesin in dogs by measuring pancreatic exocrine secretion with and without in vivo immunoneutralization of PP with a high affinity PP-antiserum.”
Effect of pancreatic polypeptide-antiserum on bombesin-stimulated pancreatic exocrine secretion in dogs“An intravenous (IV) bolus injection of bombesin (0.25 μg/kg) significantly elevated circulating levels of gastrin, PP , and CCK‐33.”
“The peak values for CCK and PP , but not gastrin, were less during second BBS infusion.”
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