Possible Interaction: Bombesin and Epinephrine

“Potentiating interactions were observed between bombesin and dibutyryladenosine 3',5'-cyclic monophosphate (DBcAMP) or epinephrine , but not between bombesin and CCK-8.”

“In addition, simultaneous administration of epinephrine and the neuropeptide, bombesin , resulted in a potentiation of gastrin release.”

“ Bombesin at 1 nmol induced significant increments of plasma noradrenaline and adrenaline levels , which were both abolished by acute bilateral adrenalectomy.”

“The elevation of plasma noradrenaline and adrenaline induced by a sub-maximal dose of bombesin (1 nmol/animal, i.c.v.)”

“administered bombesin elevates plasma noradrenaline and adrenaline by production of brain arachidonic acid in rats.”

“Central injection of the neuropeptide bombesin BN ) potently stimulates the release of epinephrine from the adrenal medulla, adrenocorticotropic hormone (ACTH) from the pituitary gland, and elicits behaviors typically associated with increased emotionality and arousal.”

“perfusion of BBS , cycling in plasma levels of motilin persisted even when phase III activity was absent and plasma levels of epinephrine rose significantly.”

“administration of bombesin (0.3 nmol) increased plasma levels of both adrenaline and noradrenaline in urethane anesthetized rats.”

“Intracerebroventricular administration of bombesin (0.3 and 3.0 nmol) increased discharge rates of the sympathetic branch as well as those of the adrenal branch of preganglionic greater splanchnic nerves.”

“Intracerebroventricular administration of bombesin induced a marked increase in plasma level of adrenaline and a slight increase in that of noradrenaline in rats anesthetized with urethane.”