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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Bombesin and Capsaicin



Research Papers that Mention the Interaction

Bombesin failed to produce a significant wheal and flare.2 Pretreatment of skin with capsaicin in all cases dramatically inhibited the flare but not the wheal.
British journal of pharmacology  •  1983  |  View Paper
In anesthetized, spontaneously breathing rats, intravenous infusion of bombesin or GRP significantly amplified the pulmonary chemoreflex responses to chemical stimulants such as capsaicin and ATP.
This sensitizing effect was further demonstrated in patch-clamp recording studies; the sensitivities of these neurons to both chemical capsaicin and ATP) and electrical stimuli were significantly enhanced by the presence of either bombesin or GRP.
American journal of physiology. Lung cellular and molecular physiology  •  2005  |  View Paper
Our results demonstrate that capsaicin treatment abolished or attenuated the suppression of glucose intake produced by BN and NMB but had no effect on the ability of GRP to reduce feeding.
Physiology & Behavior  •  2007  |  View Paper
RESULTS Ablation of sensory neurons with capsaicin negated the protective actions of bombesin but failed to reverse gastroprotection by L-DOPA or 25% ethanol.
Surgery  •  1998  |  View Paper
Systemic treatment with capsaicin , a neurotoxin which damages unmyelinated peptide-containing sensory neurons, has been shown to attenuate bombesin (BBS)-induced suppression of food intake.
Peptides  •  1992  |  View Paper
Laparotomy as well as intraperitoneal injection of capsaicin (33 and 330 microM) or hydrochloric acid (30 mM) caused a transient reduction of gastric motor activity stimulated by intravenous infusion of bombesin (200 pmol/min) and a brief fall of blood pressure (depressor effect).
Neuroscience  •  1992  |  View Paper