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Last Updated: 6 months ago

Possible Interaction: Bombesin and Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

Likewise, members of the bombesin (BB) family of peptides (including its mammalian analogues gastrin-releasing peptide (GRP) and neuromedin B (NMB)) stimulate the release of ACTH and may play a role in the mediation and/or modulation of the CRH stress response.
Behavioural Brain Research  •  2009  |  View Paper
Central administration of bombesin BN ) (into the ventricular system) increased circulating levels of ACTH , corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system.
Peptides  •  2001  |  View Paper
Central injection of the neuropeptide bombesin BN ) potently stimulates the release of epinephrine from the adrenal medulla, adrenocorticotropic hormone (ACTH) from the pituitary gland, and elicits behaviors typically associated with increased emotionality and arousal.
Life sciences  •  1998  |  View Paper
Cold stress strikingly enhanced plasma levels of ACTH, B and ALDO, and these rises lasted unchanged until 4 h. BM and NMB significantly elevated plasma concentrations of ACTH and B in both normal and stressed animals.
In light of these findings the following conclusions can be drawn: (i) BM and NMB acutely activate the HPA axis, probably by acting via … of that involved in the cold stress-induced activation of the HPA axis; and (iii) the well-known acute ALDO secretagogue effect of ACTH … BM ….
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie  •  1995  |  View Paper
Bombesin has been shown to stimulate canine ACTH and cortisol secretion in a dose-related manner.
Regulatory Peptides  •  1991  |  View Paper