Possible Interaction: Bombesin and Adrenocorticotropic Hormone

“Likewise, members of the bombesin (BB) family of peptides (including its mammalian analogues gastrin-releasing peptide (GRP) and neuromedin B (NMB)) stimulate the release of ACTH and may play a role in the mediation and/or modulation of the CRH stress response.”

“Central administration of bombesin BN ) (into the ventricular system) increased circulating levels of ACTH , corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system.”

“Central injection of the neuropeptide bombesin BN ) potently stimulates the release of epinephrine from the adrenal medulla, adrenocorticotropic hormone (ACTH) from the pituitary gland, and elicits behaviors typically associated with increased emotionality and arousal.”

“Cold stress strikingly enhanced plasma levels of ACTH, B and ALDO, and these rises lasted unchanged until 4 h. BM and NMB significantly elevated plasma concentrations of ACTH and B in both normal and stressed animals.”

“In light of these findings the following conclusions can be drawn: (i) BM and NMB acutely activate the HPA axis, probably by acting via … of that involved in the cold stress-induced activation of the HPA axis; and (iii) the well-known acute ALDO secretagogue effect of ACTH … BM ….”

“ Bombesin has been shown to stimulate canine ACTH and cortisol secretion in a dose-related manner.”