Possible Interaction: Bleomycin and Vitamin C

“In vitro studies have indicated that sensitivity to the clastogenic effects of bleomycin on chromosomes was reduced with the introduction of ascorbic acid in a dose-dependent relationship.”

“ Cellular vitamin C enhanced the ability of bleomycin by produce DSBs, which was established by direct measurements of these lesions in three cell lines.”

“Our results demonstrate strong activation effects of vitamin C on bleomycin , shifting its toxicity further toward DNA damage and making it more sensitive to manipulations of DNA repair.”

“ Vitamin C suppresses DNA breaks‐independent activation of ATM by bleomycin.”

“Supplementation with 1 g of vitamin C (ascorbic acid) per day decreased the amount of chromosome damage induced in lymphocytes by an exposure to bleomycin during the last 5 h of cell culture.”

“Intratracheal administration of bleomycin (6.5 U/kg body weight) to rats resulted in significant reduction of body weight, enzymic antioxidants (superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase) and non-enzymic antioxidants (reduced glutathione, vitamin C , vitamin E and vitamin A).”

“ AsA was found to be effective in reducing MN frequency induced by CP and BLM.”

“The degradation of calf thymus DNA, an indicator of free iron existence, was observed in the reactions of microsomes obtained from control and baicalein-treated rats with ascorbic acid in the presence of bleomycin.”

“Only ascorbic acid cotreatment had a modifying effect on BLM mutagenicity.”

“In contrast, ascorbic acid significantly enhanced DNA damage by bleomycin.”

“The data suggest that high levels of ascorbic acid supplementation may aggravate the response to bleomycin.”

“It is proposed that the action of bleomycin on DNA, and its inactivation by tissue extracts, depend, at least in part, on the presence of ascorbic acid.”