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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Bleomycin and Vitamin A

supplement:

Vitamin A

Research Papers that Mention the Interaction

Intratracheal administration of bleomycin (6.5 U/kg body weight) to rats resulted in significant reduction of body weight, enzymic antioxidants (superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase) and non-enzymic antioxidants (reduced glutathione, vitamin C, vitamin E and vitamin A).
Biological & pharmaceutical bulletin  •  2008  |  View Paper
Lung wet weight/body weight ratio 7 days after bleomycin was reduced in the vitamin A treated rats.
The percent of lung involved with pneumonitis, the lung wet weight/body weight ratio and the … also increased after bleomycin alone compared to the group pretreated with vitamin A. Rats pretreated with vitamin A demonstrated a statistically significant reduction in total … macrophage superoxide anion production 7 days after bleomycin ….
These data suggest that vitamin A attenuates bleomycin induced pulmonary damage by a mechanism which involves inhibition of bleomycin-induced alveolar macrophage superoxide anion production.
Research communications in chemical pathology and pharmacology  •  1993  |  View Paper