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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“When HeLa and HeLa‐BLMr cells after a … BLM‐free growth medium were treated with BLM , the enzyme activity was induced at a higher level (2.5–3.8 times) in … HeLa cells and was inhibited markedly in HeLa‐BLMr and slightly in HeLa cells by nicotinamide , an … enzyme.”
High Induction of Poly(ADP‐ribose) Polymerase Activity in Bleomycin‐resistant HeLa Cells“Moreover, nicotinamide treatment attenuates collagen accumulation and fibrogenesis in the bleomycin model of lung fibrosis.”
Nicotinamide induces apoptosis and reduces collagen I and pro-inflammatory cytokines expression in rat hepatic stellate cells.“These findings suggest that the development of pulmonary fibrosis induced by BLM was prevented through maintaining NAD by the administration of nicotinamide or niacin.”
“Because inhibitors of poly (ADP-ribose) synthetase have been found to influence DNA synthesis in some systems, the possibility that nicotinamide or isonicotinamide might potentiate the effect of bleomycin on DNA replication and repair was examined.”
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