Possible Interaction: Bleomycin and Naringin

“BLM significantly increased the total CAs and micronucleus frequency at a concentration of 20 µg/mL. Naringin did not show any toxicity in doses of 1, 2, and 3 µg/mL. Combined treatments of BLM and naringin (2 and 3 µg/mL) significantly reduced micronucleus formation.”

“ Naringin dose-dependently decreased the total chromosome aberrations frequency induced by BLM.”

“These results indicate that naringin could prevent BLM (20 µg/mL)-induced genotoxicity.”

“These results show that naringin has the potential of reducing the toxic effects of bleomycin and may provide supportive therapy for conventional treatment methods for idiopathic pulmonary fibrosis.”

“Our study, which was conducted on the basis of antioxidant, free radical scavenging and metal chelating properties of naringin demonstrates that naringin reduced the genotoxic effects of bleomycin and consequently increased the cell survival and therefore may act as a chemoprotective agent in clinical situations.”

“Treatment of cells with 1 mm naringin before exposure to different concentrations of bleomycin arrested the bleomycin‐induced decline in the cell survival accompanied by a significant reduction in the frequency of micronuclei when compared with bleomycin treatment alone.”