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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
Research Papers that Mention the Interaction
“We observed that melatonin markedly attenuated bleomycin (BLM)-induced experimental lung fibrosis in mice and inhibited TGF-β1-induced fibrogenesis in lung fibroblasts.”
Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway“Several reports indicate that melatonin alleviates bleomycin (BLM)-induced pulmonary fibrosis in rodent animals.”
“BACKGROUND Treatment with melatonin significantly reduces lung injury induced by bleomycin , paraquat and ischemia reperfusion.”
“ Bleomycin produced a 2.7‐fold rise in the fibrosis score that was decreased 65% by melatonin (P < 0.05) and a 1.4‐fold increase in hydroxyproline content which was completely prevented by melatonin.”
“Protein carbonyl and thiobarbituric acid reactive substances levels, which were significantly elevated in the bleomycin treated rats, were significantly attenuated by melatonin.”
“Taken together, our results demonstrate that treatment with melatonin significantly reduces lung injury induced by BLM in the mice.”
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