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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bleomycin
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“In both a cell-free system as well as two-cell systems the antiviral dependence of BLM on iron and oxidant species was demonstrated.”
Mechanism of inhibition of the human immunodeficiency virus type 1 by the oxygen radical generating agent bleomycin.“ Iron is a crucially important factor in free radical production and cytotoxic activity of bleomycin.”
The Antioxidative Effect of Chamomile, Anthocyanoside and their Combination on Bleomycin-induced Pulmonary Fibrosis in Rat“ Bleomycin is thought to be growth inhibitory by virtue of its ability to oxidatively damage DNA through its complex with iron.”
“At the 0.05 level for statistical significance, iron induced concentration-dependent DNA degradation, and this effect was enhanced by ascorbate and bleomycin.”
“The results implicate a role for iron in mediating the in vivo action of bleomycin and also reveal a potentially toxic effect, membrane peroxidation, separate from DNA damage.”
“The ability of bleomycin to produce oxygen radicals in the presence of iron and molecular oxygen appears to be related to the fibrosis.”
“The interaction of iron with bleomycin results in the activation of bleomycin to a reactive intermediate which can alter DNA or undergo self-inactivation.”
“This report demonstrates that the interaction of ferrous iron with bleomycin results in chemiluminescence, that this response is iron-specific and that the presence of DNA prevents the generation of chemiluminescence.”
“ Bleomycin acts as a ferrous oxidase which promotes the iron toxicity.”
“We found that a 1:1 complex of bleomycin and Fe can degrade plasmid DNA even in the presence of a 10(6) molar excess of EDTA over bleomycin.”
Bleomycin-iron can degrade DNA in the presence of excess ethylenediaminetetraacetic acid in vitro.“DNA strand scission by bleomycin in the presence of Cu and Fe was further characterized.”
“Remarkably, it was found that the extent of DNA degradation obtained with bleomycin in the presence of Fe and Cu was greater than that obtained with either metal ion alone.”
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