Possible Interaction: Bleomycin and Hydroxyproline

“ Bleomycin inoculation induced a robust fibrotic response as indicated by increased hydroxyproline levels and increased expression of pro‐fibrotic genes.”

“We found that the levels of serum HMGB1 and lung hydroxyproline were severely elevated after BLM administration.”

“Intratracheal injection of bleomycin to mice significantly increased not only hydroxyproline content but also chymase activity in the lung.”

“4) On ID 7, … 28, the content of hydroxyproline in the … mice in bleomycin group was significantly higher than that in blank control group and simple PBS group (t=0.99, 0.…, 0.51, 0.50, 0.50, 0.52, 0.51, P<0.05 or P<0.01). (”

“We found that bleomycin significantly increased the protein concentration in the BALF, Ashcroft score in lung tissue, and hydroxyproline contents in lung lysates.”

“ Bleomycin induced a significant elevation of PRA with a significant increase in hydroxyproline and TGF-β1 in group III.”

“ Hydroxyproline level was significantly higher in bleomycin treated rats than the other groups, and its level was decreased in the therapeutic groups, especially in the β-glucan post-bleomycin group fibrosis score, hydroxyproline and MDA levels returned to the control levels.”

“ Bleomycin induced an increase of MRI-assessed total lung volume, lung dry and wet weights, and hydroxyproline content as well as collagen amount.”

“In addition, BLM significantly increased levels of lung fibrosis markers α-SMA, hydroxyproline ( Hyp ), collagen I, Snail, and Twist, whereas significantly decreased E-cadherin expression.”

“ BLM caused significant change in BAL fluid cytokine levels and increased both HPL content and histopathological score (p<0.001 for all).”