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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“DNA strand breakage induced in cultured cells by bleomycin (BLM) was remarkably enhanced in the presence of glycerol or polyvinyl alcohol which produces an enhancement effect on BLM cytotoxicity, but not in the presence of alcohols such as methanol, ethanol, or polyethylene glycol which do not produce enhanced cytotoxicity.”
Synergetic cytotoxicity of bleomycin and polyhydric alcohols: DNA strand breakage evaluated by "comet assay".“The synergistic effect of glycerol emerged in combinations with BLM analogs (peplomycin and libromycin) as well, but not with other cytotoxic drugs such as adriamycin, neocarzinostatin, paraquat, hydrogen peroxide, and N-methyl-N-nitrosourea.”
“When a low dose of BLM (0.2 mg/kg/day) was combined with 0.5 ml of glycerol (20%) and erythritol (30%), the therapeutic gains were 1.82 and 1.88, respectively.”
“It is shown that glycerol addition to one side of BLM containing cholesterol leads to a significant decrease of its capacity, and the decrease rate is in indirect proportion to glycerol concentration.”
[Effect of glycerol on the capacity and conductivity of lipid bilayer membranes].
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