Possible Interaction: Bleomycin and Glutathione

“We show that levels of antioxidants (SOD, GSH cycle , and GST) affect cellular cytotoxic responses to bleomycin , at normal and elevated temperatures (41 to 44 degrees C), suggesting the involvement of oxidative stress.”

“Since glutathione disulfide and glutathione are a pivotal redox pair, the modulation of intracellular glutathione levels is shown to change the cytotoxicity of drugs dependent on the redox cycle, such as adriamycin and bleomycin , as well as the oxygen dependent drug neocarzinostatin.”

“Further, glutathione participates in the formation of toxic metabolites of such chemotherapeutics as azathioprine and bleomycin and may affect the cellular uptake of other agents, such as methotrexate.”

“Oxidative stress parameters, such as glutathione GSH ), malondialdehyde (MDA), and antioxidant enzyme activities were altered upon BLM treatment.”

“ Bleomycin and H2O2 significantly decreased the antioxidant capacity and GSH levels in NTera-2 cells.”

“ Bleomycin and H(2)O(2) significantly decreased antioxidant capacity and GSH levels in both cell lines.”

“The level of GSH also was higher in the BLMA group compared to the BLM group.”

“Also, BLC administration reduced tissue activities of SOD, GPx, CAT, and GSH in the lung tissue compared to control group (p < 0.01).”

“There was a marked decrease in GSH content and activities of antioxidant enzymes as a result of BLM and CP treatment.”

“ Bleomycin caused a significant decrease in the level of reduced glutathione ( GSH ), which was accompanied with significant increase in lipid peroxidation (LPO) level, and myeloperoxidase (MPO) activity, in the lung tissues.”