Possible Interaction: Bleomycin and Ferrous

“ Bleomycin forms a complex with Fe(II) and O2 in the presence or absence of DNA.”

“In the presence of Fe(II) · BLM , the ECL DNA biosensing switch undergoes an irreversible cleavage event that can trigger a significant increase in ECL intensity.”

“The chemotherapeutic agent, bleomycin , forms a 1:1complex with both Fe(III) and Fe(II).”

“It has been proposed that the pneumonitis and subsequent lung fibrosis induced by bleomycin occurs when bleomycin is complexed with ferrous iron and oxygen.”

“The results suggest that pharmacological action of bleomycin is affected by the concentrations of nucleotides as well as ferrous ions.”

“This report demonstrates that the interaction of ferrous iron with bleomycin results in chemiluminescence, that this response is iron-specific and that the presence of DNA prevents the generation of chemiluminescence.”

“In the … of Fe(II)·BLM , the hairpin DNA sequence undergoes the irreversible … event under the oxidative effect of BLM with Fe(II) as a cofactor and the intercalated Ru(phen)3(2+) released from the gold electrode, which can be transduced into a significant decrease in ECL intensity.”

“ Bleomycin (BLM) is a glycopeptide antibiotic and anti-tumor agent that targets primarily the furanose rings of DNA and in the presence of ferrous ions produces oxidative damage and DNA strand breaks.”

“ Bleomycin treatments in the presence of Fe(II) increased the rate of spheroplast formation by lytic enzymes by 5- to 40-fold.”

“The antineoplastic drug bleomycin , when complexed to Fe(II ), causes both single- and double-stranded lesions in DNA in vitro.”