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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bleomycin
supplement:
Ferric Ion
Research Papers that Mention the Interaction
“We investigated the ability of various plant flavonoids (a) to inhibit 5-lipoxygenase and cyclooxygenase activities in rat peritoneal leukocytes, (b) to inhibit lipid peroxidation in rat liver microsomes, and (c) to stimulate DNA degradation caused by the antibiotic bleomycin in the presence of ferric ions.”
Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives. Relationship to antioxidant activity and to iron ion-reducing ability.“ Intravenous bleomycin alone produced no evidence of lung injury, yet when combined with a simultaneous exposure to hyperoxia or simultaneous tracheal instillation of ferric iron or ascorbate a severe lung injury evolved.”
“These results indicate that ferric iron can potentiate bleomycin induced lung injury, and that the metal chelator desferrioxamine can have adverse effects on the development of acute lung injury.”
“Bleomycins BLMs ) can utilize H2O2 to cleave DNA in the presence of ferric ions.”
Proton-shuffle mechanism of O-O activation for formation of a high-valent oxo-iron species of bleomycin.“Preincubation of template DNA in the presence of Fe++ was necessary for bleomycin and cycloserine to exhibit marked inhibition of PCR.”
“The antitumor drug, bleomycin , interacts with either Fe(II) and O 2 or Fe(III) and H2O2 to form an activated complex which attacks DNA.”
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