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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bleomycin
supplement:
Andrographolide
Research Papers that Mention the Interaction
“Moreover, BLM induced pulmonary fibrosis in tumor-bearing mice, but BLM combined with Andro dramatically alleviated the lesion in pulmonary fibrosis by activating the SOD, suppressing MDA and HYP production, in the meanwhile attenuating the IL-1β, TNF- α, IL-6 and TGF-β1 level.”
“The study showed that BLM combined with Andro was significantly more effective than BLM alone on inhibiting the tumor growth, arresting the cell cycle at G0/G1 phase, promoting the capase-3 and capase-8 activity to induce cancer cell apoptosis.”
“Thus, it demonstrated that Andro might be a potential adjuvant therapeutic agent for BLM.”
Enhanced anti-tumor activity and reduced toxicity by combination andrographolide and bleomycin in ascitic tumor-bearing mice.“On day 21 after bleomycin stimulation, andrographolide dose-dependently inhibited the inflammatory cells and TNF-α in BALF.”
“ Andrographolide also improved the BLM mediated changes in the MMP-1/TIMP-1 ratio.”
“However, andrographolide treatment caused a reversal of the BLM induced changes after 20 or 40 days.”
Andrographolide plays an important role in bleomycin-induced pulmonary fibrosis treatment.
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