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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Sphingosine 1-Phosphate
Research Papers that Mention the Interaction
“The influence of sphingolipids, such as ceramide and its metabolite sphingosine 1-phosphate , on signal transduction pathways under cell stress is important to survival adaptation responses.”
Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.“ ER stress also increases production of the proapoptotic lipid ceramide and its antiapoptotic metabolite, sphingosine-1-phosphate (S1P).”
“LPA (20 microM) and S1P (1 microM) stimulated actin stress fiber and focal adhesion formation, increased MLC phosphorylation, and induced marked activation of Rho GTPase in HTM cells.”
“By monitoring XBP-1 mRNA splicing, a characteristic of ER stress, we demonstrate that S1P triggers ER stress in a concentration-dependent and time-dependent manner.”
“Moreover, DiH S1P , a membrane-nonpermeable S1P analog without intracellular effects also enhances ER stress.”
“Nevertheless, increases in intracellular pools of S1P , but not dihydro-S1P, induced autophagy and ER stress.”
“The recovery of membrane N-cadherin, change in cell-cell adhesion and actin stress fibers intensity in response to LPA and S1P inversely correlate with their effects on cellular invasiveness.”
“Both SPP and LPA stimulated actin stress fibre formation, which was also butan-2-ol-insensitive and inhibited by butan-1-ol.”
“Supplementation with exogenous S1P significantly reversed the activation of the PERK-eIF2α-ATF4 pathway and ATF6 during ER stress as well as the activation of GSK3β, ASK1, and JNK during MPT.”
SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition“Both LPA and S1P prevented increased transcellular permeabilities induced by PMA, and increased actin stress fiber formation in epithelial and endothelial cells.”
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