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Last Updated: 3 years ago
supplement:
Kaempferol
Research Papers that Mention the Interaction
“ConclusionsOur results suggest that luteolin induces apoptosis through activating ER stress and mitochondrial dysfunction in glioblastoma cell lines and in vivo, which provides the anti-cancer candidate to treat glioblstoma.”
Luteolin induces apoptosis by ROS/ER stress and mitochondrial dysfunction in gliomablastoma“Indeed, the inhibition of ER stress suppressed kaempferol-induced autophagy and conferred prolonged cell survival, indicating autophagic cell death.”
“Altogether, we have demonstrated the ability of kaempferol to alleviate ER stress in in vitro model.”
“We have shown that kaempferol pre-incubation significantly inhibits the expression of GRP78 (a chaperone) and CHOP ( ER stress associated pro-apoptotic transcription factor) under stressed condition.”
“Furthermore, luteolin increased the level of intracellular ROS, leading to ROS-mediated apoptosis and ER stress.”
“Together, these findings suggest that kaempferol prevents ectopic lipid accumulation and ER stress , thus restoring β-cell function through AMPK-mediated lipophagy.”
Kaempferol alleviates palmitic acid-induced lipid stores, endoplasmic reticulum stress and pancreatic β-cell dysfunction through AMPK/mTOR-mediated lipophagy.“In conclusion, luteolin improved renal function in I/R rats by reducing oxidative stress, neutrophil infiltration, inflammation, renal cell apoptosis, and expression of HMGB1 and NF-κB, and ER stress.”
“In ex vivo-Langendorff experiment, the kaempferol treatment regulated the expression of ER stress proteins-CHOP and GRP78.”
“Our results demonstrated that kaempferol induced hepatocarcinoma cell death via ER stress and CHOP-autophagy signaling pathway; kaempferol may be used as a potential chemopreventive agent for patients with hepatocellular carcinoma.”
Kaempferol induces hepatocellular carcinoma cell death via endoplasmic reticulum stress-CHOP-autophagy signaling pathway“Our results demonstrated that kaempferol induced hepatocarcinoma cell death via ER stress and CHOP-autophagy signaling pathway; kaempferol may be used as a potential chemopreventive agent for patients with hepatocellular carcinoma.”
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