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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Diindolylmethane
Research Papers that Mention the Interaction
“Because DIM toxicity in vitro is enhanced in cells undergoing nutritional deprivation and ER stress , it is possible that stressed cells in vivo, such as those within developing solid tumors, also have increased sensitivity to killing by DIM.”
Endoplasmic reticulum stress as a correlate of cytotoxicity in human tumor cells exposed to diindolylmethane in vitro“Furthermore, DIM treatment activated caspase-dependent apoptotic pathway and suppressed epithelial–mesenchymal transition (EMT) via ER stress and unfolded protein response (UPR).”
3,3′-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis
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