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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Biotin
drug:
Valproic Acid
Research Papers that Mention the Interaction
“In conclusion we showed that VPA usage reduced the serum and liver tissue BEA and impaired the biotin utilization by affecting the liver.”
“ Serum biotin levels of the VPA group were lower than the control group.”
“The alopecia which may further be observed in the patients receiving valproic acid therapy may be prevented by means of administration of biotin in a dose of 10 mg/day.”
Serum and liver tissue biotinidase enzyme activity in rats which were administrated to valproic acid“Hair loss with valproate is dose-dependent and there is a decrease in biotinidase activity during valproate treatment and can be prevented by applying biotin to experimental rats [5].”
Valproate Induced Hair Loss and Curly Hair in Bipolar Disorder
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