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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Biotin
supplement:
Pantothenic Acid
Research Papers that Mention the Interaction
“Both pantothenic acid and lipoic acid decreased significantly in uptake of biotin in the concentration-dependent manner.”
Vitreal pharmacokinetics of biotinylated ganciclovir: role of sodium-dependent multivitamin transporter expressed on retina.“Desthiobiotin and pantothenic acid significantly inhibited the uptake of biotin , whereas 2-iminobiotin and diaminobiotin were very weak inhibitors.”
“3H] biotin uptake was significantly inhibited in the presence of biotin, its structural analog desthiobiotin, pantothenic acid and lipoic acid.”
“We hypothesized that pantothenic acid reduces the absorption of biotin in lactating dairy cows.”
Effect of biotin and pantothenic acid on performance and concentrations of avidin-binding substances in blood and milk of lactating dairy cows.“ Biotin was significantly inhibited in the presence of pantothenic acid and lipoic acid.”
“ PA (0.3 μM) transport through the blood‐brain barrier was significantly inhibited by probenecid, nonanoic acid, and biotin (all 0.25 mM), but not by penicillin G, pyruvate, β‐hydroxybutyrate.”
“However, the concentration of pantothenic acid in most foods and biological fluids is approximately 200 times the concentration of biotin ; theoretically, pantothenic acid might substantially reduce biotin transport via competition.”
“ Pantothenic acid at 10 to 1,000 nmol/L reduced biotin (475 pmol/L) uptake by less than 12% (P < 0.05).”
“Several structural analogs of pantothenic acid at 1,000 nmol/L reduced biotin transport by only 7 to 15% (P = 0.13).”
Human peripheral blood mononuclear cells: ; Inhibition of biotin transport by reversible competition with pantothenic acid is quantitatively minor.
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