Possible Interaction: Biotin and Glucose

“These results indicate that the administration of a high concentrations of biotin may improve the metabolism and/or utilization of glucose in patients with non-insulin-dependent diabetes mellitus.”

“ Biotin is thus directly involved in the vitally important metabolic process of glucose and fat synthesis and can also have profound effects on other pathways by its influence on many metabolic intermediates.”

“Dietary CrHis and biotin supplementation exhibited a significant (p < 0.001) decrease in glucose (effect size = large; ƞ2 = 0.773) and TG (effect size = large; ƞ2 = 0.802) levels, and increase in HDL cholesterol compared with the exercise group.”

“Several lines of evidence have demonstrated that pharmacological concentrations of biotin affect glucose and lipid metabolism, hypertension, reproduction, development, and immunity.”

“When islets were stimulated with glucose plus biotin , the ATP/ADP ratio increased to approximately 160% of the ATP/ADP ratio in islets stimulated with glucose alone.”

“In addition, the rate and extent of uptake of biotin and natural analogues has been compared … degrades the vitamin as sole source of C, N, and S3 Often the rate of biotin uptake is … addition of glucose , is temperature and pH dependent, and …, which indicate an active transport process.”

“When the dietary requirement of biotin was met, cecal biotin greatly increased in the presence of dietary glucose , sorbitol, and sucrose but remained at a low level when dextrin was the dietary carbohydrate.”

“After supplementing spent yeast cell hydrolysate and 90 g/l of glucose with 150 μg/l of biotin , cell growth increased 32.5%, glucose utilization increased 37.6%, and succinic acid concentration was enhanced 49.0%.”

“Neither N2 nor nitrate could replace ammonium as the nitrogen source, and biotin was preferentially stimulatory for glucose cell lines.”

“ Biotin uptake by the cells was inhibited by glucose.”