Possible Interaction: Biotin and Folate

“ Biotin and folate supplementation could compensate for each other's deficiency in the repression of LTRs in Jurkat and U937 cells.”

“Here we tested the hypothesis that biotin and folate synergize in the repression of pro‐inflammatory cytokines and long‐terminal repeats (LTRs), mediated by interactions between HLCS and other chromatin proteins.”

“We conclude that biotin and folate synergize in the repression of LTRs and that these interactions are probably mediated by HLCS‐dependent epigenetic mechanisms.”

“In bile, choline and biotin increased 14- and 18-fold, respectively, whereas folate and niacin decreased by more than 50%.”

“Hence, it is proposed that concurrent administration of PhyCB, citrulline, taurine, and supranutritional doses of folate and biotin may have considerable potential for prevention and control of diabetic complications.”

“Competition also extended to biotin , whose transport was strongly inhibited (58% and 73%, respectively) by the simultaneous uptake of either folate or thiamine; biotin, however, had only a minimal effect on either folate or thiamine transport.”

“The decreased levels of the conjugated folates in presence of biotin has been attributed to the observed lowering in the levels of folylconjugate synthetase.”