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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Biotin
drug:
Carbamazepine
Research Papers that Mention the Interaction
“BACKGROUND In subjects undergoing long-term therapy with carbamazepine and/or phenytoin, reduced plasma concentrations of biotin have been reported.”
Disturbances in biotin metabolism in children undergoing long-term anticonvulsant therapy.“Clinical data demonstrate that certain antiepileptic drugs including carbamazepine (CBZ) decrease serum biotin concentration 45-50% and increase urine and serum organic acids, which is suggestive of reduced function of biotin-dependent enzymes.”
Dietary carbamazepine administration decreases liver pyruvate carboxylase activity and biotinylation by decreasing protein and mRNA expression in rats.“ Biotin status and function are decreased during oral carbamazepine (CBZ) administration in both humans and rats, but it is not known whether biotin supplementation can prevent these decreases.”
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