Possible Interaction: Biotin and Alpha-lipoic acid

“Both pantothenic acid and lipoic acid decreased significantly in uptake of biotin in the concentration-dependent manner.”

“As in the intestine, the uptake process in the liver is also specific for biotin; … analogs with a free carboxyl group on the valeric acid side-chain moiety, such as thioctic acid and … biotin uptake, while analogs with a blocked carboxyl group, … biocytin and biotin methyl ester, do not.”

“3H] biotin uptake was significantly inhibited in the presence of biotin, its structural analog desthiobiotin, pantothenic acid and lipoic acid.”

“Inhibition of the biotin uptake (25 μmol/l) was observed in the presence of 250 μmol/l dethiobiotin, bisnorbiotin, thioctic acid , and probenecid, whereas biocytin, propionic acid, lactic acid, succinic acid, citric acid, ascorbic acid, primidone and carbamazepine had no effect.”

“ Biotin was significantly inhibited in the presence of pantothenic acid and lipoic acid.”

“ Lipoic acid and biocytin were effective in inhibiting the biotin uptake.”

“Desthiobiotin, 250 microM, norbiotin, bisnorbiotin, thioctic acid , valeric acid, probenecid, and nonanoic acid inhibited the transport of 30 microM biotin , whereas other biotin derivatives, as well as biocytin and organic acids found in the urine of biotinidase-deficient patients, did not.”

“Preloading of the vesicles with biotin, desthiobiotin, norbiotin, and thioctic acid in the presence of Na+ increased initial uptake of biotin from the incubation medium (trans-stimulation).”

“Biocytin, biotin methyl ester, diaminobiotin, desthiobiotin, thioctic acid , and two other analogues inhibited biotin transport.”

“Conditions that may increase biotin requirements in humans include pregnancy, lactation, and therapy with anticonvulsants or lipoic acid.”