Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Biotin and Aldesleukin

supplement:

Biotin

Research Papers that Mention the Interaction

Overall, this study provides evidence that administration of pharmacologic doses of biotin for 14 d decreases PBMC proliferation and synthesis of interleukin-1beta and interleukin-2.
The Journal of nutrition  •  2001  |  View Paper
Transcriptional activities of genes encoding IL-2 and IL-2Rgamma were increased up to 43% in cells supplemented with diaminobiotin, desthiobiotin or biotin compared with biotin-deficient cells, as judged by luciferase activities after transfection with reporter-gene constructs.
The Journal of nutrition  •  2003  |  View Paper
Biotin has been credited with having beneficial effects on immune function despite observations that biotin supplementation causes decreased secretion of interleukin-2.
Secretion of interleukin-2 correlated negatively with biotin supply, but transcriptional activity of the interleukin-2 gene correlated positively with biotin supply, suggesting that decreased secretion of interleukin-2 by biotin-supplemented cells was not caused by decreased gene expression.
American journal of physiology. Cell physiology  •  2003  |  View Paper
This study provides evidence that biotin supply affects biotinylation of proteins, gene expression and metabolism of interleukin-2 in Jurkat cells.
The Journal of nutrition  •  2002  |  View Paper
It was shown … addition of the biostimulator to the fermentation medium resulted in increased accumulation of CoA and biotin in the mycelium of the levorin-producing culture within the first 48 hours of the growth and in their more intensive consumption at the final stages of the fermentation process.
Antibiotiki  •  1983  |  View Paper