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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Biochanin A
drug:
Saquinavir
Research Papers that Mention the Interaction
“ Biochanin A increased the first peak, yet decreased the second peak of plasma SQV levels.”
“Our study demonstrates that biochanin A can significantly reduce SQV oral bioavailability and alter SQV PK profiles in rats.”
“Results revealed that the area under the plasma concentration-time curve of SQV from time zero to time infinity (AUC0-∞) was reduced by 51.39% by biochanin A (P=0.038); while the apparent systemic clearance (CL/F) was increased by 87.62% (P=0.028).”
Reduced Oral Bioavailability and Altered Pharmacokinetics of Saquinavir by Co-administration with Biochanin A in Rats.
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