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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Biochanin A
drug:
Paclitaxel
Research Papers that Mention the Interaction
“In contrast to the in vitro results, intraperitoneal or oral administration of biochanin A did not significantly change the pharmacokinetics of doxorubicin and cyclosporine A. Moderate interaction was observed between biochanin A and paclitaxel , resulting in lower AUC values after both i.v.”
Interactions between the flavonoid biochanin A and P-glycoprotein substrates in rats: in vitro and in vivo.“With BA coadministration, the oral bioavailability and peak plasma concentration were markedly increased by 3.77- and 2.04-fold for paclitaxel , 1.75- and 1.71-fold for digoxin, but were reduced by 0.694- and 0.429-fold for fexofenadine, respectively.”
Altered oral bioavailability and pharmacokinetics of P-glycoprotein substrates by coadministration of biochanin A.
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