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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Biochanin A
supplement:
Genistein
Research Papers that Mention the Interaction
“Proliferation of HSC-41E6, HSC-45M2, and SH101-P4 stomach cancer cell lines was strongly inhibited by biochanin A and genistein , whereas other stomach, esophageal, and colon cancer lines were moderately suppressed by both compounds.”
Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract.“Different extents of metabolism were observed in the three mammary cell types; however, GEN concentrations were very low following either GEN or BCA administration in all of the three cell types.”
“ Genistein inhibits cleavage of 1-cell embryos in a concentration-dependent and reversible manner; biochanin A , which is a less potent inhibitor of tyrosine protein phosphorylation, is a less potent inhibitor of cell cleavage.”
Regulation of mouse preimplantation development: inhibitory effect of genistein, an inhibitor of tyrosine protein phosphorylation, on cleavage of one-cell embryos.“Moreover, the complex with biochanin A reveals an unusual binding mode that appears to account for its greater inhibition of 17β-HSDcl with respect to genistein.”
Structural basis for inhibition of 17β-hydroxysteroid dehydrogenases by phytoestrogens: The case of fungal 17β-HSDcl
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