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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Biguanides
supplement:
NADH
Research Papers that Mention the Interaction
“These observations imply that the biguanide causes deactivation of the glycolytic pathway and subsequently the accumulation of pyruvate and NADH and a decrease in NAD+.”
Buformin suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase.“All diguanides and phenformin but not metformin inhibited NADH oxidation in submitochondrial particles, indicative of complex I inhibition, which also corresponded closely with dehydrogenase activity in living cells measured by WST-1.”
Metformin selectively targets redox control of complex I energy transduction“ Biguanide treatment led to a significant increase in NADH in FTSECs and HGSC cells.”
Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells
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