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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Biguanides and NADH

supplement:

NADH

Research Papers that Mention the Interaction

These observations imply that the biguanide causes deactivation of the glycolytic pathway and subsequently the accumulation of pyruvate and NADH and a decrease in NAD+.
Biological & pharmaceutical bulletin  •  2006  |  View Paper
All diguanides and phenformin but not metformin inhibited NADH oxidation in submitochondrial particles, indicative of complex I inhibition, which also corresponded closely with dehydrogenase activity in living cells measured by WST-1.
Redox biology  •  2018  |  View Paper